iGEM Frankfurts combats multi-resistance with a paper strip
A GIP travel grant was awarded by the GIP XOLLX Future Lab team to the iGEM team at Goethe University Frankfurt based on the exceptional public engagement, innovative potential of the project and excellence in interdisciplinary scientific work.
The iGEM team at Goethe University Frankfurt, comprising biophysicists, chemists, computer scientists, and biologists, is tackling the critical issue of antibiotic resistance. Experts like Jim O'Neill warn that multidrug-resistant germs could surpass cancer as the leading cause of death by 2050. The Frankfurt team focuses on developing innovative methods to detect antibiotics in water, particularly in sewage treatment plants and hospitals. Their solution involves a cell biosensor on a paper strip, similar to a pregnancy test, where a synthetically modified microorganism detects antibiotics, causing a visible color change.
This complex biological task relies heavily on bioinformatics for simulating protein binding, predicting genetic interactions, and modeling signaling pathways. Despite limited support and skepticism towards synthetic biology, the team adapts by ensuring water samples are tested outside the lab, addressing concerns about genetically modified organisms.
The Frankfurt team emphasizes education and communication, actively engaging with schools, experts, and the public to discuss these pressing challenges. Despite hurdles, they remain optimistic about changing perceptions and advancing innovative science through persistent dialogue and collaboration.